mRNA vaccines use a new technology and there has been no animal or clinical experimentation to test it.
Studies on mRNA vaccines in animal models is not new.
Research using messenger RNA vaccine technology started in the 1990s and animal tests have been conducted intensively for about ten years on different types of animals (mice, monkeys...), especially during epidemics already caused by Coronaviruses, SARS-CoV (2002-2003) and MERS-CoV (2012). Based on very large amount of data, animal studies suggest that RNA vaccines could be very safe and effective in controlling epidemics.
Animal studies withthe COVID 19 vaccines has been conducted in mice, rats, and macaque monkeys and has demonstrated the safety and efficacy of these vaccines in animals. It is noteworthy to point out that the animal trials of Pfizer-BioNTech vaccine (not mentioned in the Clinical Study Protocol) are mentioned in other documents (see EU Risk management plan for Pfizer-BioNTech vaccine ).
Clinical studies of mRNA vaccines in humans is not new either. Phase 1 clinical trials in humans were conducted as early as 2011 and some trials are still ongoing in the context of research on other mRNA vaccines, in particular those against HIV, influenza, Zika and certain forms of cancer.
1-Cristiano Conte, Francesco Sogni, Paola Affanni, Licia Veronesi, Alberto Argentiero and Susanna Esposito, Vaccines against Coronaviruses: The State of the Art, in Vaccines 2020, 8(2), 309, cf. : https://doi.org/10.3390/vaccines8020309, page consultée le 27 décembre 2020*
- EU Risk management Plan du Vaccin Pfizer-BioNTech ;
- Ibid p.17 et s.
 -Pardi N, Hogan MJ, Porter FW, Weissman D. mRNA vaccines – a new era in vaccinology. Nat Rev Drug Discov. 2018 Apr;17(4):261-279. doi: 10.1038/nrd.2017.243. Epub 2018 Jan 12. PMID: 29326426; PMCID: PMC5906799